A Pokémon+High Fantasy story would be awesome!!!! Have Red (color names given to bastards/orphans) a simple ten year old with the dream of being the greatest Beastmaster ever. In this High Fantasy world pokemon are just creatures living in the world and can't be caught on balls, but tames by people with the gift of beast taming. And you tame them with magical red and white crystal spheres (think material from FF7). But, taming monsters cost energy from the tamer, in order to make a bond with the creature, so no one is able to tame more than six creatures. If you try to tame a creature stronger than yourself, you risk your life in doing so. Unless you carry spheres that have stronger magic and help tame stronger monsters (i.e. greater, ultra, master.) That's not to say, all creatures need to be tames. Some could become your friends and be your pets. The crystal spheres are for wild creatures to dangerous to tame by just being friendly. Gym leaders could be the leaders of a certain town, kind of like royalty.
IDK. Just saying that could be cool. Red with a sword battling dragons and other beast with his magical creatures at his side.